Risk factors of Carcinoma Breast
1. Female Sex ( Incidence is more in Females - 50 times more )
2. Age (Incidence increases steadily with Age>20yrs)
3. Number of menstrual cycles between menarche & 1st Full Term Pregnancy ( Longer the period- More the Risk )
4. Early menarche, late menopause
5. Breast denied of its function ( Nulliparity increases the risk and lactation is protective)
6. Previous History of Carcinoma Breast in a Patient
7. Family History of Carcinoma Breast in First Degree Relatives
( Mother, Sisters and Daughters) – BRCA 1 & 2
8. Exogenous Hormone Use ( Hormone Replacement Therapy )
9. Diet- Decreased in take of Phyto Estrogen
10. Obesity ( Due to increased conversion of Steroid hormones to Oestrodiol in the Body Fat )
11. Previous Radiation to Chest- Hodgkin’s Disease
12. Alcohol Intake
Histological Risk factors for Carcinoma Breast
1. Proliferative Breast Disease
2. Atypical Ductal Hyperplasia ( ADH ) – ( 4 - 5 Times increased risk)
3. Atypical Lobular Hyperplasia ( ALH ) – ( 4 - 5 Times increased risk)
