Risk factors of Carcinoma Breast

Risk factors of Carcinoma  Breast

                         

1.    Female Sex ( Incidence is more in Females - 50 times more )

2.   Age (Incidence increases steadily with Age>20yrs)

3.   Number of menstrual cycles between menarche & 1st Full      Term  Pregnancy ( Longer the period- More the Risk )

4.    Early menarche, late menopause

5.    Breast denied of its function ( Nulliparity increases the risk and lactation is protective)

6.    Previous History of Carcinoma Breast in a Patient

7.    Family History of Carcinoma Breast in First Degree Relatives

      ( Mother, Sisters and Daughters) – BRCA 1 & 2

8.    Exogenous Hormone Use ( Hormone Replacement Therapy )

9.    Diet- Decreased in take of Phyto Estrogen

10.  Obesity ( Due to increased conversion of Steroid hormones to Oestrodiol in  the Body Fat )

11.  Previous Radiation to Chest- Hodgkin’s Disease

12.  Alcohol Intake

Histological Risk factors for Carcinoma Breast

1.   Proliferative Breast Disease

2.   Atypical Ductal Hyperplasia ( ADH ) – ( 4 - 5 Times increased risk)

3.   Atypical Lobular Hyperplasia ( ALH ) – ( 4 - 5 Times increased risk)